MPV17L

Across TCGA patient cohorts, MPV17L mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPV17L-associated genes across cancer lineages are MIR5689, MRPS22P1, and RNU6-905P. Each is linked with MPV17L in more than 2 cancer types. Because this analysis shows association rather than direction, both MPV17L-to-partner and partner-to-MPV17L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5689 grouped by MPV17L-low versus MPV17L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPV17L→partner) and Y-score (partner→MPV17L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR5689 →	+0.436	+4.003	<.001	.001	3	3
UCEC	MRPS22P1 →	+0.063	+4.352	<.001	<.001	3	2
COAD	RNU6-905P →	+0.482	+5.251	<.001	.003	3	1
COAD	LINC01707 →	+0.173	+4.693	<.001	.007	3	1
COAD	LINC01014 →	+0.386	+4.324	<.001	.007	3	1
COAD	UBFD1P1 →	+0.132	+5.721	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

MIR5689 by MPV17L expression — UCEC

Explore this box plot interactively →