MPV17L

Across TCGA pan-cancer cohorts, MPV17L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MPV17L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MPV17L RNA is repressed in tumor relative to normal tissue. In most cancer types MPV17L is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where MPV17L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPV17L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	−1.641	<.001	12	view →
KICH	Male	IV	−3.513	<.001	10	view →
BLCA	Male	IV	−2.210	<.001	10	view →
UCEC	All	All	−1.788	<.001	6	view →
LIHC	All	III,IV	+0.895	.006	5	view →
THCA	Male	All	−0.558	.012	5	view →
KIRC	Female	II,III,IV	−0.667	.044	3	view →
READ	All	All	−1.415	.005	2	view →
LUSC	All	III,IV	−1.111	<.001	2	view →
LUSC	Female	All	+0.874	.007	2	view →
PRAD	All	All	−0.319	.022	2	view →
LUAD	Male	II,III,IV	−0.516	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

MPV17L–HNSC

Open the HNSC breakdown →