Across TCGA pan-cancer cohorts, MPTX1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MPTX1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MPTX1 RNA is repressed in tumor relative to normal tissue. In most cancer types MPTX1 is over-expressed in tumor, although a few such as HNSC and UCEC show the opposite, repressed pattern.

HNSC, UCEC, and LUSC are the cancer types where MPTX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPTX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.028	.009	5	view →
UCEC	All	All	−0.165	.007	2	view →
LUSC	Male	All	−0.028	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MPTX1 RNA expression & survival · all MPTX1 data types