MPST

Across TCGA patient cohorts, MPST mutation is significantly associated with the RNA expression of many other genes, with 935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPST-associated genes across cancer lineages are SEPTIN14P24, DNAJC28, and KRTAP20-3. Each is linked with MPST in more than 2 cancer types. Because this analysis shows association rather than direction, both MPST-to-partner and partner-to-MPST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P24 grouped by MPST-low versus MPST-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPST→partner) and Y-score (partner→MPST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SEPTIN14P24 →	+0.467	+5.038	<.001	.009	3	3
UCEC	DNAJC28 →	+0.328	+1.939	.006	.009	3	2
HNSC	KRTAP20-3 →	+0.364	+7.954	<.001	.008	3	2
SKCM	FXNP2 →	+0.130	+4.043	.002	.001	3	2
UCEC	RNU6-147P →	+0.391	+2.644	<.001	.005	3	2
SKCM	LINC02670 →	+0.026	+4.678	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 935 associations by consensus.

SEPTIN14P24 by MPST expression — LUSC

Explore this box plot interactively →