MPST

Across TCGA pan-cancer cohorts, MPST RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MPST’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MPST RNA is repressed in tumor relative to normal tissue. In most cancer types MPST is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and THCA are the cancer types where MPST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.333	<.001	8	view →
KICH	Female	II,III,IV	−1.662	<.001	7	view →
THCA	Male	All	+0.318	<.001	5	view →
BLCA	All	All	+0.528	.010	4	view →
LIHC	Male	All	+0.441	.002	3	view →
PRAD	All	All	+0.483	<.001	2	view →
LUSC	All	II,III,IV	+0.399	.006	2	view →
STAD	Male	III,IV	+0.716	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MPST–BRCA

Open the BRCA breakdown →