MPST

Across TCGA patient cohorts, MPST mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPST-associated genes across cancer lineages are ERK2, GSK-3a-b_pS21_S9, and Ku80. Each is linked with MPST in more than 1 cancer types. Because this analysis shows association rather than direction, both MPST-to-partner and partner-to-MPST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MPST-low versus MPST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPST→partner) and Y-score (partner→MPST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.213	+3.169	.022	.019	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.498	+2.459	.015	.020	3	1
UCEC	Ku80 →	+0.278	+3.179	.015	.010	3	1
UCEC	Notch1 →	+0.140	+2.820	.039	.035	3	1
UCEC	Tuberin_pT1462 →	+0.253	+2.817	.023	.036	3	1
UCEC	c-Kit →	-0.222	-2.459	.049	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by MPST expression — UCEC

Explore this box plot interactively →