MPST

Across TCGA cell cohorts, MPST RNA expression is significantly associated with the go_rna of many other GO terms, with 3,668 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPST-associated GO terms across cancer lineages are Transsulfuration, Hydrogen sulfide metabolic process, and Hydrogen sulfide biosynthetic process. Each is linked with MPST in more than 16 cancer types. Because this analysis shows association rather than direction, both MPST-to-partner and partner-to-MPST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transsulfuration grouped by MPST-low versus MPST-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPST→partner) and Y-score (partner→MPST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Transsulfuration →	+0.272	+1.145	<.001	<.001	3	17
PANCREAS	Hydrogen sulfide metabolic process →	+0.245	+0.953	<.001	<.001	3	16
BLOOD_Leukemia	Hydrogen sulfide biosynthetic process →	+0.539	+1.920	.001	<.001	3	16
BONE	Sulfur amino acid catabolic process →	+0.282	+1.170	<.001	<.001	3	16
LIVER	tRNA thio-modification →	+0.174	+1.746	<.001	.001	3	15
LIVER	tRNA wobble position uridine thiolation →	+0.127	+1.710	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,668 associations by consensus.

Transsulfuration by MPST expression — LUNG_NSCLC_LUSC

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