MPRIP

Across TCGA pan-cancer cohorts, MPRIP Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MPRIP data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MPRIP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MPRIP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, PRAD, and UCEC are the cancer types where MPRIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.181	0.655	.046	6	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
UCEC	DFS	Median	All	0.942	0.827	.027	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
BLCA	DFS	Median	IV	0.077	0.476	<.001	3	view →
SKCM	DFS	Median	II,III,IV	0.222	0.711	.037	3	view →
COAD	DFS	Median	II,III,IV	0.249	0.568	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MPRIP–KIRC (OS)

Open the KIRC breakdown →