MPRIP

Across TCGA pan-cancer cohorts, MPRIP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MPRIP’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MPRIP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MPRIP is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

LIHC, KICH, and UCEC are the cancer types where MPRIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPRIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.159	<.001	8	view →
KICH	Female	All	−0.932	<.001	8	view →
UCEC	All	All	−1.413	<.001	6	view →
LUSC	Female	All	−1.116	<.001	6	view →
BRCA	All	All	−0.916	<.001	6	view →
LUAD	Female	II,III,IV	−0.753	<.001	6	view →
CHOL	Male	All	+2.141	<.001	5	view →
BLCA	All	All	−0.543	.001	5	view →
KIRP	Male	All	−0.641	.001	2	view →
HNSC	Female	III,IV	+0.582	.013	2	view →
PRAD	All	All	−0.376	.001	2	view →
STAD	Male	II,III,IV	+0.658	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MPRIP–LIHC

Open the LIHC breakdown →