MPRIP

Across TCGA patient cohorts, MPRIP mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPRIP-associated genes across cancer lineages are ATM, eIF4E, and FOXO3a_pS318_S321. Each is linked with MPRIP in more than 2 cancer types. Because this analysis shows association rather than direction, both MPRIP-to-partner and partner-to-MPRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MPRIP-low versus MPRIP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPRIP→partner) and Y-score (partner→MPRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.579	-2.000	<.001	.027	3	3
COAD	eIF4E →	+0.200	+1.725	.003	.025	3	2
COAD	FOXO3a_pS318_S321 →	-0.149	-3.974	.017	<.001	3	2
COAD	GAPDH →	+0.602	+3.334	.001	.005	3	2
COAD	PCNA →	+0.317	+1.887	<.001	.029	3	2
COAD	RAD51 →	+0.194	+3.459	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

ATM by MPRIP expression — COAD

Explore this box plot interactively →