MPRIP

Across TCGA cell cohorts, MPRIP mutation is significantly associated with the RNA expression of many other genes, with 87 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPRIP-associated genes across cancer lineages are MROH5, IFNA8, and OR10H5. Each is linked with MPRIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MPRIP-to-partner and partner-to-MPRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MROH5 grouped by MPRIP-low versus MPRIP-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPRIP→partner) and Y-score (partner→MPRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	2
SOFT_TISSUE	IFNA8 →	+0.034	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR10H5 →	+0.029	+4.930	<.001	.008	3	1
SOFT_TISSUE	SCGB1C1 →	+0.073	+5.977	<.001	.001	3	1
SOFT_TISSUE	TAS2R38 →	+0.028	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUAD	TSPAN16 →	+0.038	+2.742	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

MROH5 by MPRIP expression — SOFT_TISSUE

Explore this box plot interactively →