MPPED2-AS1

Across TCGA pan-cancer cohorts, MPPED2-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MPPED2-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MPPED2-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MPPED2-AS1 expression acts as an unfavorable survival marker, although some lineages such as ACC and UVM show a favorable association.

ACC, UVM, and LGG are the cancer types where MPPED2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.652	0.285	<.001	105	view →
UVM	OS	Quartile	All	0.863	0.484	.004	58	view →
LGG	DFS	Median	All	0.638	0.831	<.001	49	view →
READ	OS	Tertile	III,IV	0.747	0.948	.003	41	view →
HNSC	DFS	Tertile	IV	0.645	0.484	.005	32	view →
LUAD	DFS	Tertile	IV	0.441	0.761	.011	18	view →
UCS	OS	Tertile	IV	0.206	0.675	.024	18	view →
MESO	OS	Median	All	0.466	0.305	.018	17	view →
STAD	OS	Tertile	II,III,IV	0.454	0.645	.015	15	view →
OV	DFS	Quartile	IV	0.276	0.554	.016	12	view →
PCPG	OS	Median	All	0.941	1.000	.030	12	view →
BLCA	OS	Median	III,IV	0.175	0.378	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MPPED2-AS1–ACC (DFS)

Open the ACC breakdown →