MPPED2-AS1

Across TCGA pan-cancer cohorts, MPPED2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MPPED2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MPPED2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MPPED2-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where MPPED2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPPED2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.707	<.001	12	view →
THCA	All	IV	−3.345	<.001	11	view →
KIRP	All	All	−1.641	<.001	11	view →
STAD	All	II,III,IV	−0.575	<.001	7	view →
BRCA	All	III,IV	−0.361	<.001	6	view →
LIHC	Male	II,III,IV	+0.079	<.001	6	view →
COAD	All	All	−0.182	<.001	5	view →
READ	All	III,IV	−0.245	.019	4	view →
UCEC	All	IV	−2.315	.043	2	view →
PRAD	All	All	−0.756	<.001	2	view →
LUSC	All	All	+0.298	.001	2	view →
CHOL	All	All	+0.058	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MPPED2-AS1–KIRC

Open the KIRC breakdown →