MPP6

Across TCGA cell cohorts, MPP6 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPP6-associated genes across cancer lineages are MT1HL1, IFNA21, and FCN2. Each is linked with MPP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP6-to-partner and partner-to-MPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1HL1 grouped by MPP6-low versus MPP6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP6→partner) and Y-score (partner→MPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MT1HL1 →	+0.173	+6.266	<.001	<.001	3	1
BLOOD_Lymphoma	IFNA21 →	+0.197	+3.925	<.001	.005	3	1
BLOOD_Lymphoma	FCN2 →	+0.051	+5.129	<.001	<.001	3	1
BLOOD_Lymphoma	SPATS1 →	+0.748	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	KIAA1210 →	+0.102	+3.843	.001	.007	3	1
LARGE_INTESTINE	ACTR8 →	+0.432	+3.215	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MT1HL1 by MPP6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →