MPP2

Across TCGA patient cohorts, MPP2 mutation is significantly associated with the RNA expression of many other genes, with 2,879 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP2-associated genes across cancer lineages are MIR4299, SENP3-EIF4A1, and MTATP6P21. Each is linked with MPP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPP2-to-partner and partner-to-MPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4299 grouped by MPP2-low versus MPP2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP2→partner) and Y-score (partner→MPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4299 →	+0.989	+5.219	<.001	.006	3	3
UCEC	SENP3-EIF4A1 →	+0.089	+2.074	<.001	<.001	3	3
SARC	MTATP6P21 →	+0.247	+5.345	<.001	.005	3	3
SKCM	CHAF1A →	+0.560	+3.006	.001	<.001	3	3
UCEC	NCAPH2 →	+0.521	+2.839	<.001	<.001	3	3
UCEC	RAD51 →	+0.551	+1.765	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,879 associations by consensus.

MIR4299 by MPP2 expression — READ

Explore this box plot interactively →