MPP1

Across TCGA patient cohorts, MPP1 mutation is significantly associated with the RNA expression of many other genes, with 2,564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPP1-associated genes across cancer lineages are MACC1-AS1, RN7SL191P, and RNU6-748P. Each is linked with MPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP1-to-partner and partner-to-MPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MACC1-AS1 grouped by MPP1-low versus MPP1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP1→partner) and Y-score (partner→MPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MACC1-AS1 →	+0.052	+4.878	.002	.005	3	2
LIHC	RN7SL191P →	+0.192	+5.149	<.001	.003	3	2
COAD	RNU6-748P →	+0.779	+4.199	<.001	.002	3	2
COAD	MIR7975 →	+0.329	+5.734	<.001	<.001	3	2
CESC	MIR449A →	+0.408	+6.584	<.001	<.001	3	2
CESC	RNA5SP131 →	+0.341	+5.342	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,564 associations by consensus.

MACC1-AS1 by MPP1 expression — LIHC

Explore this box plot interactively →