MPO

Across TCGA patient cohorts, MPO RNA expression is significantly associated with the protein abundance of many other proteins, with 9,498 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MPO-associated proteins across cancer lineages are THEMIS2, RGS14, and GMFG. Each is linked with MPO in more than 4 cancer types. Because this analysis shows association rather than direction, both MPO-to-partner and partner-to-MPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MPO versus THEMIS2 in LSCC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MPO→partner) and Y-score (partner→MPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	THEMIS2 →	+0.539	+0.321	<.001	<.001	3	5
LSCC	RGS14 →	+0.463	+0.256	<.001	<.001	3	5
LSCC	GMFG →	+0.671	+0.246	<.001	.001	3	5
BRCA	RASGRP2 →	+0.471	+0.201	<.001	.002	3	5
LSCC	PREX1 →	+0.348	+0.212	<.001	<.001	3	4
LSCC	VAV1 →	+0.496	+0.255	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,498 associations by consensus.

MPO vs THEMIS2 — LSCC

Explore this scatter interactively →