MPO

Across TCGA pan-cancer cohorts, MPO RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MPO’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MPO RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MPO is over-expressed in tumor, although a few such as LUSC and HNSC show the opposite, repressed pattern.

COAD, LUSC, and HNSC are the cancer types where MPO tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPO RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.514	.001	10	view →
LUSC	Male	All	−0.535	<.001	7	view →
HNSC	All	All	−0.679	.002	6	view →
BRCA	All	III,IV	−0.286	<.001	6	view →
KICH	Female	All	−0.167	.020	3	view →
KIRP	Male	All	+0.235	.032	2	view →
PRAD	All	All	−0.217	<.001	2	view →
THCA	Male	All	−0.107	.006	2	view →
READ	All	II,III,IV	+0.212	.032	1	view →
LIHC	All	All	−0.070	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

MPO–COAD

Open the COAD breakdown →