MPO

Across TCGA patient cohorts, MPO protein abundance is significantly associated with the RNA expression of many other genes, with 17,617 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MPO-associated genes across cancer lineages are IL1B, FCGR3B, and S100A12. Each is linked with MPO in more than 9 cancer types. Because this analysis shows association rather than direction, both MPO-to-partner and partner-to-MPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MPO versus IL1B in COAD, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPO→partner) and Y-score (partner→MPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL1B →	+1.425	+0.898	<.001	<.001	3	10
PDAC	FCGR3B →	+1.846	+1.289	<.001	<.001	3	10
HNSC	S100A12 →	+1.729	+0.729	<.001	<.001	3	10
LSCC	CXCL1 →	+2.023	+0.794	<.001	<.001	3	10
LUAD	CXCL8 →	+2.689	+1.206	<.001	<.001	3	10
LSCC	CEACAM3 →	+0.860	+1.126	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,617 associations by consensus.

MPO vs IL1B — COAD

Explore this scatter interactively →