MPO

Across TCGA patient cohorts, MPO mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPO-associated genes across cancer lineages are p27_pT198, ATM, and c-Met_pY1235. Each is linked with MPO in more than 2 cancer types. Because this analysis shows association rather than direction, both MPO-to-partner and partner-to-MPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by MPO-low versus MPO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPO→partner) and Y-score (partner→MPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.090	+1.662	.016	.011	3	3
UCEC	ATM →	-0.588	-2.000	<.001	.003	3	3
UCEC	c-Met_pY1235 →	+0.056	+1.495	.033	.034	3	3
SKCM	GAPDH →	+0.672	+2.169	.002	.003	3	3
UCEC	MEK1 →	+0.299	+1.584	.020	.034	3	2
LUSC	Collagen-VI →	-0.262	-3.000	.041	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

p27_pT198 by MPO expression — UCEC

Explore this box plot interactively →