MPO

Across TCGA cell cohorts, MPO mutation is significantly associated with the RNA expression of many other genes, with 331 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPO-associated genes across cancer lineages are PDIK1L, OR10Q1, and CUEDC2. Each is linked with MPO in more than 2 cancer types. Because this analysis shows association rather than direction, both MPO-to-partner and partner-to-MPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDIK1L grouped by MPO-low versus MPO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPO→partner) and Y-score (partner→MPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDIK1L →	+0.550	+3.234	.005	.004	3	3
BLOOD_Leukemia	OR10Q1 →	+0.019	+4.384	<.001	.006	3	2
LARGE_INTESTINE	CUEDC2 →	+0.598	+3.234	.001	.004	3	2
LARGE_INTESTINE	SCO1 →	+0.678	+3.169	<.001	.006	3	2
LARGE_INTESTINE	ATOH7 →	+0.202	+3.432	.008	.002	3	2
BREAST	KRTAP4-9 →	+0.134	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 331 associations by consensus.

PDIK1L by MPO expression — LARGE_INTESTINE

Explore this box plot interactively →