MPI

Across TCGA pan-cancer cohorts, MPI mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MPI data layer compared with 29 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MPI mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MPI expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where MPI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.985	0.104	.024	15	view →
PDAC	DFS	Quartile	All	0.584	0.282	.001	13	view →
HNSC	OS	Median	II,III,IV	0.928	0.994	.015	12	view →
UCEC	DFS	Quartile	All	0.958	0.729	.017	10	view →
LUAD	OS	Tertile	II,III,IV	0.501	1.000	.012	4	view →
LSCC	OS	Quartile	II,III,IV	0.808	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MPI–CCRCC (OS)

Open the CCRCC breakdown →