MPI

Across TCGA pan-cancer cohorts, MPI RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MPI’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MPI RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MPI is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where MPI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+1.250	<.001	12	view →
KICH	All	III,IV	−0.930	<.001	10	view →
COAD	Female	II,III,IV	−0.605	<.001	10	view →
THCA	Male	IV	−0.633	<.001	9	view →
LUAD	Male	II,III,IV	+0.576	<.001	9	view →
LIHC	Male	All	+0.757	<.001	8	view →
LUSC	Female	II,III,IV	+0.787	<.001	6	view →
HNSC	All	All	+0.197	.030	5	view →
READ	All	All	−0.671	.011	4	view →
CHOL	All	All	+0.667	<.001	2	view →
PRAD	All	All	+0.408	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MPI–KIRC

Open the KIRC breakdown →