MPI

Across TCGA patient cohorts, MPI mutation is significantly associated with the RNA expression of many other genes, with 973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPI-associated genes across cancer lineages are E2F6P1, RPL7P35, and RNU6-419P. Each is linked with MPI in more than 2 cancer types. Because this analysis shows association rather than direction, both MPI-to-partner and partner-to-MPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F6P1 grouped by MPI-low versus MPI-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPI→partner) and Y-score (partner→MPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	E2F6P1 →	+0.071	+6.179	<.001	<.001	3	3
UCEC	RPL7P35 →	+0.079	+2.289	.002	.004	3	2
UCEC	RNU6-419P →	+0.361	+2.146	.005	.006	3	2
LUAD	SNORA3C →	+0.350	+6.087	<.001	.002	3	2
BRCA	LINC01646 →	+0.059	+6.215	<.001	.001	3	2
LUAD	KRASP1 →	+0.132	+5.279	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 973 associations by consensus.

E2F6P1 by MPI expression — SKCM

Explore this box plot interactively →