MPI

Across TCGA cell cohorts, MPI mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MPI-associated genes across cancer lineages are GPR26, TRIM42, and NKX2-6. Each is linked with MPI in more than 1 cancer types. Because this analysis shows association rather than direction, both MPI-to-partner and partner-to-MPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by MPI-low versus MPI-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPI→partner) and Y-score (partner→MPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPR26 →	+0.077	+5.539	<.001	.003	3	1
BLOOD_Leukemia	TRIM42 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	LRRC55 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR56A5 →	+0.043	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GPR26 by MPI expression — BLOOD_Leukemia

Explore this box plot interactively →