MPHOSPH9

Across TCGA patient cohorts, MPHOSPH9 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPHOSPH9-associated genes across cancer lineages are eIF4E, p38-MAPK_pT180_Y182, and PCNA. Each is linked with MPHOSPH9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPHOSPH9-to-partner and partner-to-MPHOSPH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MPHOSPH9-low versus MPHOSPH9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH9→partner) and Y-score (partner→MPHOSPH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.137	+1.765	.033	.013	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.317	-1.925	.021	.004	3	2
UCEC	PCNA →	+0.203	+1.947	.002	<.001	3	2
UCEC	ASNS →	+0.367	+1.765	<.001	.013	3	2
UCEC	4E-BP1 →	+0.200	+2.700	.015	.005	3	2
SKCM	Caveolin-1 →	-1.064	-3.000	.002	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by MPHOSPH9 expression — UCEC

Explore this box plot interactively →