MPHOSPH9

Across TCGA cell cohorts, MPHOSPH9 mutation is significantly associated with the RNA expression of many other genes, with 176 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MPHOSPH9-associated genes across cancer lineages are OR1L3, ALG6, and CALHM4. Each is linked with MPHOSPH9 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPHOSPH9-to-partner and partner-to-MPHOSPH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by MPHOSPH9-low versus MPHOSPH9-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH9→partner) and Y-score (partner→MPHOSPH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.013	+3.415	<.001	.001	3	3
LARGE_INTESTINE	ALG6 →	+0.510	+3.169	.001	.006	3	2
BLOOD_Leukemia	CALHM4 →	+0.020	+3.269	<.001	.007	3	2
BLOOD_Leukemia	B4GALNT2 →	+0.018	+3.744	<.001	.003	3	2
BLOOD_Leukemia	SNTG2 →	+1.177	+3.491	<.001	.009	3	2
SKIN	DNAH10OS →	+0.391	+3.215	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

OR1L3 by MPHOSPH9 expression — SKIN

Explore this box plot interactively →