Across TCGA cell cohorts, MPHOSPH8 mutation is significantly associated with the mutation status of many other genes, with 3,553 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPHOSPH8-associated genes across cancer lineages are PEAK1, TPR, and ANKS1A. Each is linked with MPHOSPH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPHOSPH8-to-partner and partner-to-MPHOSPH8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH8→partner) and Y-score (partner→MPHOSPH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PEAK1 →	+4.014	+4.969	.008	.008	1	3
SKIN	TPR →	+3.169	+4.548	.004	.004	1	3
SKIN	ANKS1A →	+4.392	+4.392	.009	.009	1	3
LARGE_INTESTINE	FLNA →	+1.693	+2.287	.005	.005	1	3
LARGE_INTESTINE	TOGARAM1 →	+2.011	+2.895	<.001	<.001	1	3
LARGE_INTESTINE	DCAF12L1 →	+2.056	+2.313	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,553 associations by consensus.

Exploration

MPHOSPH8 survival (RNA) · tumor vs normal (RNA) · all MPHOSPH8 data types