MPHOSPH10

Across TCGA pan-cancer cohorts, MPHOSPH10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MPHOSPH10 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MPHOSPH10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MPHOSPH10 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where MPHOSPH10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.602	0.887	<.001	76	view →
PDAC	OS	Median	III,IV	0.292	0.571	.006	18	view →
LSCC	DFS	Median	II,III,IV	0.892	0.510	.001	13	view →
HNSC	DFS	Quartile	IV	0.444	0.814	.001	4	view →
LUAD	DFS	Median	II,III,IV	0.954	0.752	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MPHOSPH10–CCRCC (DFS)

Open the CCRCC breakdown →