MPHOSPH10

Across TCGA patient cohorts, MPHOSPH10 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPHOSPH10-associated genes across cancer lineages are 14-3-3_beta, ATM, and eIF4E. Each is linked with MPHOSPH10 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPHOSPH10-to-partner and partner-to-MPHOSPH10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MPHOSPH10-low versus MPHOSPH10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH10→partner) and Y-score (partner→MPHOSPH10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.236	-2.974	.025	.036	3	3
COAD	ATM →	-0.706	-2.991	<.001	.036	3	3
UCEC	eIF4E →	+0.174	+1.652	.012	.006	3	3
COAD	4E-BP1 →	+0.285	+3.008	.012	.019	3	2
COAD	Di-Ras3 →	-0.311	-2.991	.002	.036	3	2
UCEC	JNK2 →	+0.301	+3.114	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

14-3-3_beta by MPHOSPH10 expression — COAD

Explore this box plot interactively →