MPDZ

Across TCGA patient cohorts, MPDZ protein abundance is significantly associated with the RNA expression of many other genes, with 8,165 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MPDZ-associated genes across cancer lineages are FERMT2, PTPN21, and FAT3. Each is linked with MPDZ in more than 5 cancer types. Because this analysis shows association rather than direction, both MPDZ-to-partner and partner-to-MPDZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MPDZ versus FERMT2 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPDZ→partner) and Y-score (partner→MPDZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FERMT2 →	+0.997	+0.234	<.001	<.001	3	6
BRCA	PTPN21 →	+0.620	+0.160	<.001	.006	3	5
UCEC	FAT3 →	+0.680	+0.193	.002	.004	3	5
UCEC	RHOJ →	+0.633	+0.247	.006	.001	3	5
CCRCC	TEK →	+0.854	+0.221	<.001	<.001	3	4
BRCA	NFIB →	+0.785	+0.208	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,165 associations by consensus.

MPDZ vs FERMT2 — BRCA

Explore this scatter interactively →