MPDZ

Across TCGA pan-cancer cohorts, MPDZ RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MPDZ’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MPDZ RNA is repressed in tumor relative to normal tissue. In most cancer types MPDZ is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and COAD are the cancer types where MPDZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPDZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	III,IV	−1.866	<.001	8	view →
KICH	Male	All	−1.451	<.001	8	view →
COAD	Female	II,III,IV	−0.785	<.001	8	view →
BLCA	Male	All	−1.372	.004	7	view →
UCEC	All	All	−1.630	<.001	6	view →
LUAD	Female	III,IV	−1.247	<.001	6	view →
BRCA	All	III,IV	−1.050	<.001	6	view →
KIRC	Male	II,III,IV	−0.622	<.001	6	view →
THCA	All	II,III,IV	−0.574	.006	5	view →
LIHC	All	II,III,IV	−0.737	.001	4	view →
CHOL	All	All	−1.175	<.001	3	view →
STAD	All	All	−0.809	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MPDZ–LUSC

Open the LUSC breakdown →