MPDZ

Across TCGA patient cohorts, MPDZ mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPDZ-associated genes across cancer lineages are ASNS, Bak, and Caspase-7-cleavedD198. Each is linked with MPDZ in more than 4 cancer types. Because this analysis shows association rather than direction, both MPDZ-to-partner and partner-to-MPDZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MPDZ-low versus MPDZ-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPDZ→partner) and Y-score (partner→MPDZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.566	+3.000	<.001	<.001	3	5
BLCA	Bak →	+0.185	+2.820	.037	.035	3	4
COAD	Caspase-7-cleavedD198 →	+0.725	+1.593	.004	.011	3	4
BLCA	NF-kB-p65_pS536 →	-0.451	-3.000	.009	.036	3	3
COAD	PDCD4 →	-0.478	-2.798	<.001	<.001	3	3
UCEC	TFRC →	+0.354	+0.917	.008	.025	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

ASNS by MPDZ expression — COAD

Explore this box plot interactively →