MPDZ

Across TCGA cell cohorts, MPDZ mutation is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MPDZ-associated genes across cancer lineages are SMYD1, OR2B2, and HCRTR2. Each is linked with MPDZ in more than 1 cancer types. Because this analysis shows association rather than direction, both MPDZ-to-partner and partner-to-MPDZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMYD1 grouped by MPDZ-low versus MPDZ-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPDZ→partner) and Y-score (partner→MPDZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SMYD1 →	+0.101	+3.947	<.001	.003	3	2
CNS	OR2B2 →	+0.104	+2.824	<.001	.005	3	2
BLOOD_Leukemia	HCRTR2 →	+0.011	+2.744	<.001	<.001	3	2
BLOOD_Leukemia	NPIPA5 →	+1.219	+3.614	.007	<.001	3	2
BLOOD_Leukemia	SH3D21 →	+0.762	+2.489	.003	.007	3	2
BLOOD_Myeloma	GATA5 →	+0.031	+3.514	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

SMYD1 by MPDZ expression — KIDNEY

Explore this box plot interactively →