MOXD1

Across TCGA patient cohorts, MOXD1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOXD1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and GSK3-a-b. Each is linked with MOXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOXD1-to-partner and partner-to-MOXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MOXD1-low versus MOXD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOXD1→partner) and Y-score (partner→MOXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_beta →	-0.183	-3.000	.006	.035	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.415	.020	.046	3	2
UCEC	GSK3-a-b →	-0.104	-1.415	.039	.046	3	2
UCEC	MEK1 →	+0.357	+2.169	.009	.003	3	2
UCEC	ATM →	-0.481	-1.765	.004	.014	3	2
UCEC	Caspase-8 →	-0.272	-2.662	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

14-3-3_beta by MOXD1 expression — SKCM

Explore this box plot interactively →