Across TCGA patient cohorts, MOSMO mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOSMO-associated genes across cancer lineages are RNU6-6P, MIR6129, and RNA5SP414. Each is linked with MOSMO in more than 1 cancer types. Because this analysis shows association rather than direction, both MOSMO-to-partner and partner-to-MOSMO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOSMO→partner) and Y-score (partner→MOSMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-6P →	+0.723	+3.034	<.001	.003	3	1
UCEC	MIR6129 →	+0.773	+3.496	<.001	<.001	3	1
UCEC	RNA5SP414 →	+0.981	+2.933	<.001	.006	3	1
UCEC	MIR7702 →	+0.415	+5.253	<.001	.001	3	1
UCEC	RN7SL478P →	+0.265	+2.676	.004	.007	3	1
UCEC	SNX3P1Y →	+0.199	+5.671	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

MOSMO survival (RNA) · tumor vs normal (RNA) · all MOSMO data types