MOS

Across TCGA cell cohorts, MOS RNA expression is significantly associated with the mutation status of many other genes, with 83 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible MOS-associated genes across cancer lineages are ANK2, COL6A2, and ADCY10. Each is linked with MOS in more than 1 cancer types. Because this analysis shows association rather than direction, both MOS-to-partner and partner-to-MOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANK2 grouped by MOS-low versus MOS-high in CNS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOS→partner) and Y-score (partner→MOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ANK2 →	+3.244	+0.020	.005	.002	3	2
BLOOD_Myeloma	COL6A2 →	+4.807	+0.040	.006	<.001	3	1
BLOOD_Myeloma	ADCY10 →	+4.807	+0.040	.006	<.001	3	1
BLOOD_Myeloma	HEATR3 →	+4.807	+0.040	.006	<.001	3	1
BLOOD_Myeloma	BABAM2 →	+4.807	+0.040	.006	<.001	3	1
BLOOD_Myeloma	NELL1 →	+4.807	+0.040	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

ANK2 by MOS expression — CNS

Explore this box plot interactively →