MOS

Across TCGA pan-cancer cohorts, MOS RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated MOS data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MOS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MOS expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, ACC, and KIRC are the cancer types where MOS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.213	0.718	.002	81	view →
ACC	DFS	Tertile	All	0.039	0.778	<.001	57	view →
KIRC	DFS	Tertile	II,III,IV	1.000	0.527	.028	48	view →
CESC	DFS	Tertile	All	0.592	0.826	.026	36	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	36	view →
LIHC	DFS	Tertile	III,IV	0.079	0.354	<.001	27	view →
UCS	DFS	Tertile	II,III,IV	0.619	0.241	.018	20	view →
BLCA	OS	Tertile	III,IV	0.141	0.581	.011	18	view →
LUAD	DFS	Tertile	All	0.499	0.687	.031	15	view →
STAD	OS	Tertile	IV	0.158	0.473	.023	13	view →
SKCM	DFS	Tertile	All	0.930	0.729	.024	12	view →
SARC	OS	Tertile	All	0.668	0.845	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

MOS–UVM (OS)

Open the UVM breakdown →