MOS

Across TCGA cell cohorts, MOS mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MOS-associated genes across cancer lineages are USP17L17, FBXW10, and NUPR2. Each is linked with MOS in more than 1 cancer types. Because this analysis shows association rather than direction, both MOS-to-partner and partner-to-MOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L17 grouped by MOS-low versus MOS-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOS→partner) and Y-score (partner→MOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP17L17 →	+0.013	+6.022	<.001	.001	3	1
LARGE_INTESTINE	FBXW10 →	+0.282	+3.491	<.001	.004	3	1
LARGE_INTESTINE	NUPR2 →	+0.205	+2.688	.001	.008	3	1
BLOOD_Lymphoma	PCARE →	+0.038	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	IFNL4 →	+0.018	+4.191	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

USP17L17 by MOS expression — SKIN

Explore this box plot interactively →