MORC4

Across TCGA cell cohorts, MORC4 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MORC4-associated genes across cancer lineages are RIPPLY1, TCF21, and CBLN4. Each is linked with MORC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MORC4-to-partner and partner-to-MORC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIPPLY1 grouped by MORC4-low versus MORC4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORC4→partner) and Y-score (partner→MORC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RIPPLY1 →	+0.024	+4.191	.009	.007	3	2
BLOOD_Leukemia	TCF21 →	+0.019	+4.705	<.001	.003	3	2
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	2
OVARY	DPEP2NB →	+0.026	+2.736	.002	.008	3	2
OESOPHAGUS	MINDY4B →	+0.070	+4.906	<.001	.006	3	1
BREAST	TARM1 →	+0.018	+4.196	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

RIPPLY1 by MORC4 expression — BLOOD_Lymphoma

Explore this box plot interactively →