MORC4

Across TCGA pan-cancer cohorts, MORC4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MORC4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MORC4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MORC4 is over-expressed in tumor.

COAD, HNSC, and STAD are the cancer types where MORC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MORC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.589	<.001	11	view →
HNSC	Male	All	+0.799	<.001	10	view →
STAD	Male	II,III,IV	+1.312	<.001	8	view →
BLCA	All	All	+0.641	.001	8	view →
LUSC	Male	II,III,IV	+0.964	<.001	6	view →
LIHC	All	All	+0.643	<.001	6	view →
CHOL	All	All	+1.337	<.001	5	view →
LUAD	All	All	+0.282	.001	5	view →
KIRP	All	III,IV	+0.685	.019	4	view →
READ	All	All	+1.282	.006	2	view →
PRAD	All	All	+0.257	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MORC4–COAD

Open the COAD breakdown →