MORC2

Across TCGA pan-cancer cohorts, MORC2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MORC2 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MORC2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MORC2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

HNSC, CCRCC, and COAD are the cancer types where MORC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.505	0.738	.014	23	view →
CCRCC	OS	Median	III,IV	0.927	0.656	.003	20	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	12	view →
GBM	OS	Quartile	All	0.564	0.287	.021	4	view →
PDAC	OS	Median	IV	0.836	0.491	.024	4	view →
LUAD	OS	Quartile	III,IV	0.993	0.557	.040	3	view →
LSCC	DFS	Median	II,III,IV	0.815	0.581	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MORC2–HNSC (DFS)

Open the HNSC breakdown →