MORC2

Across TCGA pan-cancer cohorts, MORC2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MORC2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MORC2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MORC2 is over-expressed in tumor.

HNSC, COAD, and KIRC are the cancer types where MORC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MORC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.395	<.001	12	view →
COAD	Male	IV	+1.275	<.001	12	view →
KIRC	Female	All	+0.583	<.001	12	view →
LIHC	Female	II,III,IV	+1.340	<.001	9	view →
LUAD	All	III,IV	+0.897	<.001	9	view →
LUSC	Female	All	+1.584	<.001	8	view →
STAD	Male	II,III,IV	+1.358	<.001	8	view →
BLCA	All	All	+0.566	<.001	8	view →
KIRP	All	II,III,IV	+0.746	<.001	7	view →
BRCA	All	All	+0.435	<.001	6	view →
CHOL	Male	All	+2.824	<.001	5	view →
READ	All	All	+0.907	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MORC2–HNSC

Open the HNSC breakdown →