MORC2

Across TCGA cell cohorts, MORC2 mutation is significantly associated with the RNA expression of many other genes, with 884 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MORC2-associated genes across cancer lineages are OR13C3, PLA2G2D, and IL25. Each is linked with MORC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MORC2-to-partner and partner-to-MORC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C3 grouped by MORC2-low versus MORC2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORC2→partner) and Y-score (partner→MORC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR13C3 →	+0.015	+5.312	.008	<.001	3	2
LUNG_NSCLC_LUSC	PLA2G2D →	+0.006	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	IL25 →	+0.026	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ACTRT2 →	+0.053	+4.643	.001	.008	3	1
LUNG_NSCLC_LUSC	OR1L3 →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR10V1 →	+0.073	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 884 associations by consensus.

OR13C3 by MORC2 expression — BREAST

Explore this box plot interactively →