MORC1

Across TCGA pan-cancer cohorts, MORC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MORC1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MORC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MORC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where MORC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.212	0.869	.001	10	view →
HNSC	OS	Quartile	All	0.857	0.635	.034	5	view →
PDAC	DFS	Tertile	All	0.804	1.000	.046	2	view →
LSCC	OS	Quartile	II,III,IV	0.783	0.973	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MORC1–LUAD (DFS)

Open the LUAD breakdown →