MORC1

Across TCGA pan-cancer cohorts, MORC1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MORC1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MORC1 RNA is repressed in tumor relative to normal tissue. In most cancer types MORC1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where MORC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MORC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.058	<.001	7	view →
KICH	All	II,III,IV	−0.045	<.001	7	view →
BLCA	Male	All	−0.433	.026	2	view →
PRAD	All	All	−0.165	<.001	2	view →
READ	All	All	−0.047	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MORC1–COAD

Open the COAD breakdown →