MORC1

Across TCGA patient cohorts, MORC1 mutation is significantly associated with the RNA expression of many other genes, with 4,399 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MORC1-associated genes across cancer lineages are UQCRH, HJURP, and PSMC3IP. Each is linked with MORC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MORC1-to-partner and partner-to-MORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRH grouped by MORC1-low versus MORC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORC1→partner) and Y-score (partner→MORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UQCRH →	+0.294	+1.288	<.001	.001	3	5
UCEC	HJURP →	+0.443	+1.958	.004	.002	3	4
UCEC	PSMC3IP →	+0.552	+1.680	<.001	<.001	3	4
SKCM	COQ3 →	+0.324	+1.683	<.001	<.001	3	4
UCEC	RFC3 →	+0.459	+1.455	.004	.005	3	4
SKCM	TROAP →	+0.368	+1.507	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,399 associations by consensus.

UQCRH by MORC1 expression — SKCM

Explore this box plot interactively →