MORC1

Across TCGA patient cohorts, MORC1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MORC1-associated genes across cancer lineages are CDK1, eIF4E, and Caspase-7-cleavedD198. Each is linked with MORC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MORC1-to-partner and partner-to-MORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by MORC1-low versus MORC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORC1→partner) and Y-score (partner→MORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.114	+1.247	.011	.041	3	5
UCEC	eIF4E →	+0.162	+1.584	.010	.002	3	4
UCEC	Caspase-7-cleavedD198 →	+0.521	+1.534	.003	.008	3	4
LUSC	FoxM1 →	+0.257	+3.340	.003	.004	3	3
UCEC	Rab25 →	-0.303	-1.378	.002	.008	3	3
SKCM	Chk1 →	+0.097	+0.966	.032	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

CDK1 by MORC1 expression — UCEC

Explore this box plot interactively →