MORC1

Across TCGA cell cohorts, MORC1 mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MORC1-associated genes across cancer lineages are OR8B3, TEX26, and OR8B12. Each is linked with MORC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MORC1-to-partner and partner-to-MORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B3 grouped by MORC1-low versus MORC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORC1→partner) and Y-score (partner→MORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B3 →	+0.029	+2.786	<.001	.007	3	2
LUNG_SCLC	TEX26 →	+0.055	+2.874	.006	.007	3	2
LUNG_NSCLC_LUAD	OR8B12 →	+0.050	+3.149	<.001	.002	3	2
LUNG_NSCLC_LUAD	OR8D1 →	+0.063	+3.080	<.001	.002	3	2
LUNG_NSCLC_LUAD	TARM1 →	+0.016	+3.925	<.001	<.001	3	2
LUNG_NSCLC_LUAD	OR8D2 →	+0.068	+2.786	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

OR8B3 by MORC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →