MON1B

Across TCGA pan-cancer cohorts, MON1B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MON1B data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MON1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MON1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, PDAC, and GBM are the cancer types where MON1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.935	0.777	.018	16	view →
PDAC	OS	Median	II,III,IV	0.393	0.603	.022	11	view →
GBM	DFS	Quartile	All	0.779	0.546	.013	9	view →
LUAD	DFS	Median	III,IV	0.315	0.948	.008	4	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.048	1	view →
CCRCC	OS	Quartile	All	0.786	0.951	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MON1B–UCEC (DFS)

Open the UCEC breakdown →